c-Myc phosphorylation by PKCζ represses prostate tumorigenesis

Studies showing reduced PKCζ expression or enzymatic activity in different types of human cancers support the clinical relevance of PKCζ as a tumor suppressor. However, the in vivo role of PKCζ and its mechanisms of action in prostate cancer remain unclear. Here we demonstrate that the genetic inactivation of PKCζ in mice results in invasive prostate carcinoma in vivo in the context of phosphatase and tensin homolog deficiency…”


Loss of tumor suppressor SPOP releases cancer potential of SRC-3

Mutations in a protein called SPOP disarm it, allowing another protein called steroid receptor coactivator-3 to encourage the proliferation and spread of prostate cancer cells, researchers report.


Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain unclear. By combining ChIP sequencing with microarray-based gene profiling, we determined that ERBB3 is upregulated by FOXD3, a transcription factor that promotes resistance to RAF inhibitors in melanoma…”


Imatinib and prostate cancer: lessons learned from targeting the platelet-derived growth factor receptor

The platelet derived growth factor (PDGF) signaling pathway has been implicated in both epithelial and stromal mechanisms of prostate cancer progression and postulated as a target for therapy in bone metastases. Imatinib mesylate is a potent inhibitor of the platelet-derived growth factor receptor (PDGFR) and its activity has been tested in preclinical models and in Phase I and II clinical trials…”


Smoking Sooner after Waking Is Associated with Higher Lung Cancer Risk

Smokers who have their first cigarette sooner after waking are at higher risk for lung cancer, researchers have found. Those who smoke immediately after waking have higher blood levels of NNAL, a sign of carcinogens absorbed from tobacco, compared to those who smoke their first cigarette later in the day. The results hold even for those who do not smoke more cigarettes overall. The researchers suggest that smoking upon waking may reflect greater tobacco dependence, leading smokers to inhale more deeply and absorb more carcinogens.

Research paper: http://cebp.aacrjournals.org/content/early/2013/03/27/1055-9965.EPI-12-0842.abstract


Looking Good Helps People with Cancer Feel Better, Too

Cancer treatments can extend and even save lives, but the cosmetic side effects can devastate a person’s sense of self. These changes in appearance—from dry, itchy skin to loss of hair, eyebrows, and eyelashes to disfiguring surgery—can also lead to social isolation. Changes to the face are particularly distressing. Ways of coping with altered looks include makeup and wigs as well as physical activity and therapy. Women with cancer can get free beauty tips from makeup artists and wig stylists through the Look Good…Feel Better program, which is offered at more than 3,000 hospitals and community centers across the country.


U.S. Cancer Survivors Projected to Jump 30% over Next Decade

The number of cancer survivors in the U.S. will rise from 13.7 million today to 18.0 million in 2022, according to the American Association for Cancer Research. This increase will be driven by the aging population, with two-thirds of cancer survivors being age 65 years or older within 10 years. Today, women with breast cancer account for about one-fifth of survivors and men with prostate cancer account for another one-fifth, reflecting strides in diagnosis and treatment. Five-year survival rates are now nearly 89% for breast cancer and nearly 100% for prostate cancer. However, people with lung cancer account for just 3% of today’s survivors, underscoring the need for better ways of diagnosing and treating this illness.


U.S. Cancer Survivors Projected to Jump 30% over Next Decade

The number of cancer survivors in the U.S. will rise from 13.7 million today to 18.0 million in 2022, according to the American Association for Cancer Research. This increase will be driven by the aging population, with two-thirds of cancer survivors being age 65 years or older within 10 years. Today, women with breast cancer account for about one-fifth of survivors and men with prostate cancer account for another one-fifth, reflecting strides in diagnosis and treatment. Five-year survival rates are now nearly 89% for breast cancer and nearly 100% for prostate cancer. However, people with lung cancer account for just 3% of today’s survivors, underscoring the need for better ways of diagnosing and treating this illness.


U.S. Cancer Survivors Projected to Jump 30% over Next Decade

The number of cancer survivors in the U.S. will rise from 13.7 million today to 18.0 million in 2022, according to the American Association for Cancer Research. This increase will be driven by the aging population, with two-thirds of cancer survivors being age 65 years or older within 10 years. Today, women with breast cancer account for about one-fifth of survivors and men with prostate cancer account for another one-fifth, reflecting strides in diagnosis and treatment. Five-year survival rates are now nearly 89% for breast cancer and nearly 100% for prostate cancer. However, people with lung cancer account for just 3% of today’s survivors, underscoring the need for better ways of diagnosing and treating this illness.