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Q I was diagnosed with stage IIB adenocarcinoma of the lung in July 2013. I underwent a lobectomy, followed by cisplatin/alimta and radiation therapy. In October 2014, a brain metastasis was found in my parietal lobe, and excised by craniotomy and then treated with SRS. In January 2015, my doctor found a cerebellar brain met, which we treated with SRS then surgical removal. In October 2015 this area had to be re-irradiated, and now in January 2016, my MRI showed that it is enlarged, and there is a new tumor in the frontal lobe. My neurosurgeon thinks that the old spot is “pseudo-progression,” but the new tumor is real. My radiation oncologist said no more radiation to the brain. There were no mutations found in any of my tumors; my oncologist thinks I should find a clinical trial. Any suggestions for relevant trials in Florida?
A Brain metastases limit your eligibility for some trials, unfortunately, but several trials might be a good fit if your new brain lesion is asymptomatic. Below is a list of trials in FL, all of which either accept patients with asymptomatic mets, like you, or don’t mention brain metastases as one of the exclusion criteria:
NCT02000947: Combines MEDI4736 and tremelimumab, two promising immunotherapy drugs. In Tampa.
NCT02423343: Combines galunisertib (a targeted drug) with the immunotherapy drug nivolumab (Opdivo). Nivolumab is approved for lung cancer, and may work even better when combined with a second drug that acts in a different way. In Tampa.
NCT02451930: Combines necitumumab, a targeted drug, with Keytruda. In Fort Myers and St. Petersburg.
NCT02309177: Tests nivolumab and chemotherapy. In Tampa.
NCT02646748: Combines Keytruda with a targeted drug. In Port St. Lucie.
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The time it takes for medical ideas to diffuse through the community when one misses a critical talk or paper.
The life expectancy of a patient with metastatic melanoma. This number has not changed in decades.
The variance of 5-year survival rates for similar patients depending on where they are treated and by whom.
The number of lives we estimate can be saved annually by optimizing and expanding the use of available drugs.
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