Alpelisib Active in PIK3CA-Altered Solid Tumors


“Alpelisib (BYL719) induced a disease control rate (DCR) of 58.2% in patients with advanced solid tumors, according to results from a phase Ia study published in the Journal of Clinical Oncology.

“Treatment with the oral PIK3CA selective inhibitor led to a stable disease rate of 52.2%. Thirteen (9.7%) patients maintained stable disease for more than 24 weeks.

“Investigators reported ‘encouraging signs of antitumor activity’ in patients with PIK3CA-mutant, ER-positive/HER2-negative breast cancer, and other PIK3CA-altered advanced solid tumors.”

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