MRI Improved Mammography Screening Sensitivity for Older BRCA Mutation Carriers

“The addition of MRI to mammography significantly improved screening sensitivity among women who harbored BRCA1 or BRCA2 mutations, according to study results.

“The sensitivity of the screening combination also was comparable among women aged older than 50 years and those aged younger than 50 years, results showed.

“Xuan-Anh Phi, PhD, of University Medical Center Groningen in the Netherlands, and colleagues pooled individual patient data from six screening trials of high-risk individuals.

“The trials comprised a combined 1,951 women with BRCA1/2 mutations. The median age of the entire population was 41 years; 16.9% were aged 50 to 59 years and 5.5% were aged 60 years or older.

“Of the breast cancers detected, 141 occurred in women aged younger than 50 years, and 43 occurred in women aged 50 years or older.

“MRI detected 78.8% of the cancers, and mammography detected 38.6%. The combination of MRI and mammography detected 88.6% of the cancers and was associated with a significant improvement in screening sensitivity compared with mammography alone (93.4% vs. 39.6%; P˂.001). However, the combination of both screening methods was associated with a reduced specificity compared with mammography alone (80.3% vs. 93.6%; P=.0016).”