Neoadjuvant Chemotherapy for Breast Cancer Increases Chances of Lumpectomy, Decreases Chances of Mastectomy

“Patients with larger malignant tumors of the breast who undergo chemotherapy before a breast cancer operation are more likely to undergo a lumpectomy than a mastectomy, according to a study published by Killelea et al in the Journal of the American College of Surgeons.

“Study investigators from Yale University School of Medicine and Yale University Comprehensive Cancer Center also determined that rates of neoadjuvant chemotherapy had increased significantly through the 5-year study period, possibly because of the FDA approval of new chemotherapy agents…

“ ‘Going forward, it will be interesting to see whether or not the use of neoadjuvant therapy continues to rise as newer drugs and agents are being developed all the time,’ Dr. Killelea said. ‘It will also be interesting to watch what happens to the rate of breast conservation over time. We don’t know. That’s why it’s so important for us to have a database like NCDB.’ ”