New System Finds and Targets Vulnerabilities in Lung Cancer Cells

Excerpt:

“Genetic changes that help lung cancer thrive also make it vulnerable to a promising experimental drug, according to a study led by researchers from Perlmutter Cancer at NYU Langone Health, and published online October 2 in Nature Medicine.

“Specifically, the study found that mutations in the DNA code for the gene KEAP1 help lung adenocarcinoma  counter a process called oxidative stress, in which molecules known as reactive oxygen species (ROS) are created as a side effect of ‘burning’ fuel to make energy. Cancer cells need extra fuel to support abnormal growth, produce more ROS, and depend more for survival on naturally occurring antioxidants that keep ROS from damaging cell parts.”

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