Tumor-specific Cytotoxic T Cells are Crucial for Efficacy of Immunomodulatory Antibodies in Patients with Lung Cancer

In this review, we discuss tumor-induced impairment of cytotoxic T-cells (CTLs) and experimental treatments that can stimulate T-cell responses and optimize specific CTL function. We discuss 2 types of immune cells with known suppressive capacity on CTLs that are of pivotal importance in patients with lung cancer: regulatory T cells and myeloid-derived suppressor cells.