Drugs Prevent Heart Damage During Breast Cancer Treatment, Study Show

Excerpt:

“Heart medication taken in combination with chemotherapy reduces the risk of serious cardiovascular damage in patients with early-stage breast cancer, according to results from a new landmark clinical trial.

“Existing research has shown some cancer therapies such as Herceptin greatly improve survival rates for early-stage breast cancer, but come with a fivefold risk of heart failure—a devastating condition as life-threatening as the cancer itself.

“A new five-year study, led by researchers at the University of Alberta and Alberta Health Services and funded by the Canadian Institutes of Health Research (CIHR) and Alberta Cancer Foundation, shows that two kinds of heart medications, beta blockers and ACE inhibitors, effectively prevent a drop in heart function from cancer treatment.”

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Drugs Prevent Heart Damage during Breast Cancer Treatment, Study Shows

“Heart medication taken in combination with chemotherapy reduces the risk of serious cardiovascular damage in patients with early-stage breast cancer, according to results from a new landmark clinical trial.

“Existing research has shown some cancer therapies such as Herceptin greatly improve survival rates for , but come with a fivefold risk of heart failure—a devastating condition as life-threatening as the cancer itself.

“A new five-year study, led by researchers at the University of Alberta and Alberta Health Services and funded by the Canadian Institutes for Health Research (CIHR) and Alberta Cancer Foundation, shows that two kinds of heart medications, beta blockers and ACE inhibitors, effectively prevent a drop in heart function from cancer treatment.”


ACE Inhibitor Protects Heart and Lungs from Radiation Damage in Rats

Lung and breast cancers are often treated with radiation, but repeated high doses can also harm healthy tissues in the lungs and heart. New research suggests that both organs can be protected during radiation with a drug called captopril, an ACE inhibitor that is commonly used to treat cardiovascular disease. Radiation causes fibrosis (excess connective tissue) in the heart, diminishing blood flow to—and so damaging—the lungs. However, captopril decreases fibrosis in irradiated hearts and, therefore, also protects the lungs in rats, researchers reported at the European Society for Radiotherapy and Oncology’s 2013 forum. The researchers are now designing a clinical trial to see if captopril also protects against radiation damage in people.


ACE Inhibitor Protects Heart and Lungs from Radiation Damage in Rats

Lung and breast cancers are often treated with radiation, but repeated high doses can also harm healthy tissues in the lungs and heart. New research suggests that both organs can be protected during radiation with a drug called captopril, an ACE inhibitor that is commonly used to treat cardiovascular disease. Radiation causes fibrosis (excess connective tissue) in the heart, diminishing blood flow to—and so damaging—the lungs. However, captopril decreases fibrosis in irradiated hearts and, therefore, also protects the lungs in rats, researchers reported at the European Society for Radiotherapy and Oncology’s 2013 forum. The researchers are now designing a clinical trial to see if captopril also protects against radiation damage in people.


ACE Inhibitor Protects Heart and Lungs from Radiation Damage in Rats

Lung and breast cancers are often treated with radiation, but repeated high doses can also harm healthy tissues in the lungs and heart. New research suggests that both organs can be protected during radiation with a drug called captopril, an ACE inhibitor that is commonly used to treat cardiovascular disease. Radiation causes fibrosis (excess connective tissue) in the heart, diminishing blood flow to—and so damaging—the lungs. However, captopril decreases fibrosis in irradiated hearts and, therefore, also protects the lungs in rats, researchers reported at the European Society for Radiotherapy and Oncology’s 2013 forum. The researchers are now designing a clinical trial to see if captopril also protects against radiation damage in people.