“There is controversy over how best to treat patients after they’ve undergone surgery for prostate cancer. Does one wait until the cancer comes back or provide men with additional radiation therapy to prevent cancer recurrence? Now, a new study from Thomas Jefferson University shows that a genomic tool can help doctors and patients make a more informed decision.
” ‘We are moving away from treating everyone the same,’ says first author Robert Den, M.D., Assistant Professor of Radiation Oncology and Cancer Biology at Thomas Jefferson University. ‘Genomic tools are letting us gauge which cancers are more aggressive and should be treated earlier with radiation, and which ones are unlikely to benefit from additional therapy.’
“Although surgery for prostate cancer is meant to be curative, in some men, the cancer can regrow. Doctors have developed high risk criteria based on clinical factors, but these criteria are imperfect predictors of cancer returning, or recurrence. Only about 50 percent of high risk patients ever go on to develop metastases, raising the question of whether those who receive additional therapy are being overtreated.
“In an attempt to better understand how to treat their patient population, researchers led by Drs. Den and Adam Dicker, M.D., Ph.D., Chairman of the Department of Radiation Oncology at Jefferson, together with other members of the Kimmel Cancer Center Genitourinary team including Dr. Leonard Gomella, Chairman of the Department of Urology, assessed whether a genomic test designed to predict prostate cancer metastasis could also predict which patients would most benefit from radiation treatment after surgery.
“The test, called Decipher, from the genome diagnostics company GenomeDx, generates a gene signature from a patient’s cancer tissue sample. Based on this signature, the test stratifies patients into high, intermediate and low risk for cancer recurrence and metastases.”