Differential Androgen Deprivation Therapies with Anti-Androgens of Casodex or MDV3100 vs Anti-Androgen Receptor of ASC-J9 Lead to Promote vs Suppress Prostate Cancer Metastasis

“Despite the fact that androgen deprivation therapy (ADT) can effectively reduce prostate tumor size, its effect on prostate cancer (PCa) metastasis remains unclear. We examined the existing data of the ADT treated PCa patients to analyze therapy effects on primary tumors size, prostate specific antigen (PSA) values, and metastatic incidence. We found the current ADT might lead to primary tumors reduction with PSA decreases, yet metastases increase in some PCa patients.”

The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity

  • A subset of chromatin-bound AR is regulated by Siah2, in concert with NCOR1.
  • Siah2 regulates select AR target genes implicated in PCa proliferation and motility.
  • Growth of castration-resistant PCa models is inhibited upon Siah2 knockdown.
  • Siah2 expression is reduced during ADT and increased in CRPC.