Blood-Based Assays Are Addition, But Not Replacement for Lung Tissue Biopsies

Excerpt:

“The boom of blood-based biomarkers has led to a turning point in clinical practice for physicians treating patients with non–small cell lung cancer (NSCLC). While tissue biopsies remain the standard approach, plasma assays—if positive—can direct patients to a first-line targeted treatment quicker.

” ‘Blood-based testing does have a role in patients with NSCLC,’ said Leora Horn, MD, MSc. ‘The blood can be potentially used as a surrogate for markers for directing for therapy. But if blood testing is negative, it is not enough to say that a patient is not positive. Those patients do need to go on to get a biopsy.’ ”

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Updates to NSCLC Guidelines Make Testing at Diagnosis, Resistance Essential

Excerpt:

“Updates to the National Comprehensive Cancer Network (NCCN) guidelines for the management of advanced non–small cell lung cancer (NSCLC) stress the importance of multiplexed biomarker testing at diagnosis to aid in the selection of appropriate first-line and subsequent lines of therapy, said presenters at the 2017 NCCN Annual Conference.

“The latest version of the guidelines recommends that PD-L1, in addition to molecular analysis, be employed as a biomarker to direct initial therapy, with ≥50% expression established as the threshold for a positive result. The PD-L1 test ‘decides whether a patient has enough of the marker to warrant initial immunotherapy,’ said presenter Gregory J. Riely, MD, PhD.”

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Journal of Clinical Oncology Special Series in Precision Oncology

The Journal of Clinical Oncology presents a special series of review papers on precision oncology.


Journal of Clinical Oncology Special Series in Precision Oncology

The Journal of Clinical Oncology presents a special series of review papers on precision oncology.


Journal of Clinical Oncology Special Series in Precision Oncology

The Journal of Clinical Oncology presents a special series of review papers on precision oncology.


Prostate Cancer Gene Test May Aid Surveillance

“A gene-based assay for prostate cancer significantly improved identification of high-risk tumors, which could aid selection of men for active surveillance, according to researchers…”


Surveys Reveal Opportunity for Medical Community to Fully Embrace Biomarker Testing in Lung Cancer

“Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) today announced results of two surveys that explored how pulmonologists and pathologists are incorporating biomarker testing into the care of patients with lung cancer. The results point to an increased role of these physicians in biomarker testing as well as greater multidisciplinary collaboration. However, they also reveal that an opportunity exists to improve how soon these tests are requested…”