BPA Stimulates Growth of Breast Cancer Cells, Diminishes Effect of Treatment

BPA

“Bisphenol A (BPA), a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at an annual meeting of endocrine scientists.

“The researchers found that the chemical, at levels typically found in human blood, could also affect growth of an aggressive hormone-independent subtype of breast cancer cells called inflammatory breast cancer and diminish the effectiveness of treatments for the disease.

” ‘We set out to determine whether routine exposures to common chemicals such as those in plastics, pesticides and insecticides could influence the effectiveness of breast cancer treatments,’ said corresponding author Gayathri Devi, Ph.D., associate professor of surgery at Duke. ‘BPA was one of the top chemicals to show growth stimulatory effects in breast cancer cells.’ “


BPA Exposure During Fetal Development Raises Risk of Precancerous Prostate Lesions

“A new study has found for the first time that the endocrine-disrupting chemical bisphenol A (BPA) reprograms the developing prostate, making the gland more susceptible to precancerous lesions and other diseases later in a man’s life. The results will be reported Sunday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.

” ‘By using two novel models of human prostate development involving embryonic stem cells, this study is the first to show that low doses of BPA can actually reprogram human fetal prostate tissue in a manner that raises the risk of prostate diseases as men age,’ said the study’s presenting author, Esther Calderon-Gierszal, a PhD student at the University of Illinois at Chicago, Chicago, IL.”


BPA Linked to Prostate Cancer, Study Shows

“Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men’s urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.

“This research, published in the March 3 edition of PLOS ONE, provides the first evidence that urinary BPA levels may help predict prostate cancer and that disruption of a cell duplication cycle through exposure to low-dose BPA may cause cancer development in the prostate.

“BPA, an environmental pollutant with estrogen activity, is used to make hard, clear plastic and is common in many food product containers. It has been linked to neurological defects, diabetes and a number of cancers, including breast and prostate.”


BPA Exposure Early in Life Raises The Risk of Prostate Cancer

Early exposure to the chemical BPA is linked to the development of prostate cancer later in life, according to results from a new clinical study conducted at the University of Illinois in Chicago. BPA is a chemical commonly found in plastic food storage containers, water bottles, and the lining of canned goods, and is thought to act as an estrogen—a hormone that can sometimes promote cancer. To study its effects, researchers implanted mice with developing human prostate cancer cells and fed them BPA in doses similar to what people encounter in their daily lives. The results of the study concluded that mice exposed to BPA had a 33 percent risk of developing prostate cancer, while those not exposed had a 12 percent risk. The chemical is thought to ‘reprogram’ developing prostate cancer cells, making them more susceptible to the cancer causing effects of estrogens later in life.