Diabetes Plus Anticancer Drug Combination Targets Melanoma Cells Unresponsive to Standard Treatments


Researchers at the Wistar Institute in Philadelphia, Pennsylvania, recently developed a combination approach to target melanoma tumor cells that are particularly resistant to both chemotherapy and targeted therapies, such as vemurafenib. A combination of anti-melanoma drugs with an anti-diabetes drug was better able to target all of the cells in a tumor than the anti-melanoma drugs alone. The combination therapy even proved effective against cells that are usually resistant to therapy and are thought to be responsible for at least some of the resistance patients develop to melanoma treatment. Continue reading…


Dysfunctional Oxidative Phosphorylation Makes Malignant Melanoma Cells Addicted to Glycolysis Driven by the V600EBRAF Oncogene

Oncogene addiction describes how cancer cells exhibit dependence on single oncogenes to escape apoptosis and senescence. While oncogene addiction constitutes the basis for new cancer treatment strategies targeting individual kinases and pathways activated by oncogenic mutations, the biochemical basis for this addiction is largely unknown. Here we provide evidence for a metabolic rationale behind the addiction to V600EBRAF in two malignant melanoma cell lines…”


Hundreds of Potential Drug Targets to Starve Cancer Tumors Identifed

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer, as well as hundreds of potential drug targets that could cut off a tumor’s fuel supply or…


Hundreds of Potential Drug Targets to Starve Cancer Tumors Identifed

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer, as well as hundreds of potential drug targets that could cut off a tumor’s fuel supply or…


Hundreds of Potential Drug Targets to Starve Cancer Tumors Identifed

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer, as well as hundreds of potential drug targets that could cut off a tumor’s fuel supply or…