Gene Changes ID Resistant Prostate Cancer

“Any alteration in a genetically unstable region of prostate cancer cells significantly increased the odds of treatment failure, according to a preliminary study that suggests the potential for a test to identify treatment-resistant disease. Treatment failure within 5 years occurred in 36% of intermediate-risk patients with alterations in common fragile sites (CFSs) versus 10% in similar patients with no CFS alterations. Multivariate analysis showed that even one CFS alteration almost tripled the 5-year risk of treatment failure, Alireza Fotouhi Ghiam, MD, of the University of Toronto, reported here at the American Society for Radiation Oncology meeting.”

Unstable Chromosomes Linked to Less Favorable Response to Radiation Therapy and Surgery in Prostate Cancer Patients

“Detailed evaluation of a prostate cancer tumor biopsy may predict treatment outcomes for image-guided radiation therapy (IGRT) or surgery for prostate cancer, according to research presented today at the American Society for Radiation Oncology’s (ASTRO’s) 55th Annual Meeting. The study results indicate that patients who have abnormal levels of breaks at common fragile sites (CFSs), sites within the chromosomes that are sensitive to DNA damage, are more likely to have their cancer to return—treatment failure. These CFSs break abnormalities are usually associated with instability of the cell’s DNA, a phenomenon that is particularly associated with cancer.”