Unstable Chromosomes Linked to Less Favorable Response to Radiation Therapy and Surgery in Prostate Cancer Patients

“Detailed evaluation of a prostate cancer tumor biopsy may predict treatment outcomes for image-guided radiation therapy (IGRT) or surgery for prostate cancer, according to research presented today at the American Society for Radiation Oncology’s (ASTRO’s) 55th Annual Meeting. The study results indicate that patients who have abnormal levels of breaks at common fragile sites (CFSs), sites within the chromosomes that are sensitive to DNA damage, are more likely to have their cancer to return—treatment failure. These CFSs break abnormalities are usually associated with instability of the cell’s DNA, a phenomenon that is particularly associated with cancer.”