Chronic Inflammation Linked to 'High-Grade' Prostate Cancer

“Men who show signs of chronic inflammation in non-cancerous prostate tissue may have nearly twice the risk of actually having prostate cancer than those with no inflammation, according to results of a new study. The link between persistent inflammation and cancer was even stronger for men with so-called high-grade prostate cancer — those with a Gleason score between 7 and 10 — indicating the presence of the most aggressive and rapidly growing prostate cancers.”


Inflammation in Prostate May Reduce Cancer Risk

“Doctors at the North Shore-LIJ Health System have discovered that increased inflammation in the prostate may predict reduced risk for prostate cancer. The findings are published online in Cancer. Prostate cancer is one of the most common cancers in men, with an estimated 240,000 new cases diagnosed every year–it kills approximately 30,000 men annually. The prostate is a small gland that produces fluid that nourishes and transports sperm. When the cancer is detected early while still confined to the prostate gland, there is a much better chance of successful treatment–according to the American Cancer Society, a 5-year relative survival rate is 100% when prostate cancer is detected early and there is no sign that the cancer has spread outside of the prostate. Previous studies have found that chronic inflammation contributes to several forms of cancer–an estimated 20% of adult cancers can be attributed to chronic inflammatory conditions. To evaluate if inflammation in the prostate increases the risk of cancer in the gland, Daniel Moreira, MD, a urologist at the North Shore-LIJ Health System, and his colleagues conducted a clinical trial.”