The nanopharmaceutical CRLX101, a novel inhibitor of topoisomerase-1 and hypoxia-inducible factor (HIF)-1 alpha, may be capable of overcoming resistance of tumors to antiangiogenic agents, according to preclinical and early clinical studies that have evaluated CRLX101 in combination with bevacizumab (Avastin) and other antiangiogenic agents.
Results from a phase II clinical trial show that Cerulean Pharma’s anticancer drug CRLX101 did not increase survival for patients with previously treated non-small cell lung cancer (NSCLC). However, CRLX101 did shrink tumor size. Cerulean took a risk by focusing on overall survival; early clinical trials often measure drug effectiveness by looking at less-challenging measures, such as treatment response rate or time to cancer worsening. Several other clinical trials of CRLX101 in different cancers, including small cell lung cancer (SCLC), are still ongoing. More details about the drug and the trial can be found at: http://www.xconomy.com/boston/2013/03/06/cerulean-pharma-arrives-at-moment-of-truth-with-cancer-drug/.
Cerulean Pharma Inc. announced that a randomized Phase 2b study of its experimental cancer treatment, CRLX101, in patients with advanced non-small cell lung cancer (NSCLC) did not meet its primary efficacy endpoint, overall survival benefit. Consistent with earlier clinical trials, CRLX101 showed signals of activity, including tumor reductions that meet RECIST criteria, and a favorable safety profile. CRLX101 is being studied in four other ongoing clinical trials.