Editor’s note: The American American Society of Clinical Oncology (ASCO) and Cancer Care Ontario (CCO) have jointly published a new guideline for treating metastatic castration-resistant prostate cancer (mCRPC). The guideline says that androgen deprivation therapy (ADT) should be the foundation of treatment, and should be given along with certain drugs. The guideline specifies which kinds of patients should receive which drugs, in addition to ADT.
“Indefinite continuation of androgen deprivation therapy (ADT) remains the cornerstone of systemic treatment for metastatic castration-resistant prostate cancer (mCRPC), augmented by new agents, according to a joint guideline from American and Canadian oncology groups.
“In addition to ADT (medical or surgical), clinicians should offer patients with mCRPC abiraterone (Zytiga) plus prednisone, enzalutamide (Xtandi), and radium-223 (Xofigo), all of which have favorable benefit-harm profiles, the guideline indicated. Patients also may be offered docetaxel plus prednisone, but should be thoroughly informed of potential toxicity.
“Other systemic agents have niche roles in the treatment of mCRPC, as recommended by the American Society of Clinical Oncology (ASCO) and Cancer Care Ontario (CCO). The guideline was published online in the Journal of Clinical Oncology and is available on the ASCO website.”