Final TH3RESA, EMILIA Results Confirm Role of Trastuzumab Emtansine in HER2+ Breast Cancer

Excerpt:

“Final results from two large phase III trials confirm that the drug-antibody conjugate trastuzumab emtansine improves overall survival (OS) over other treatment options in patients with previously treated HER2-positive metastatic breast cancer. The results of the EMILIA and TH3RESA trials confirm the agent’s role in this setting.

“Trastuzumab emtansine, which links the antibody trastuzumab with the cytotoxic microtubule inhibitor DM1, was approved based on earlier results of the EMILIA study. The new analysis of that trial offers approximately twice the length of follow-up, at a median of 24.1 months.”

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Final TH3RESA, EMILIA Results Confirm Role of Trastuzumab Emtansine in HER2+ Breast Cancer

Excerpt:

“Final results from two large phase III trials confirm that the drug-antibody conjugate trastuzumab emtansine improves overall survival (OS) over other treatment options in patients with previously treated HER2-positive metastatic breast cancer. The results of the EMILIA and TH3RESA trials confirm the agent’s role in this setting.

“Trastuzumab emtansine, which links the antibody trastuzumab with the cytotoxic microtubule inhibitor DM1, was approved based on earlier results of the EMILIA study. The new analysis of that trial offers approximately twice the length of follow-up, at a median of 24.1 months.”

Go to full article.

If you’re wondering whether this story applies to your own cancer case or a loved one’s, we invite you to use our ASK Cancer Commons service.


First Clinical Trial of New Cancer Drug IMGN289 Begins

A phase I clinical trial marks the start of early testing for new cancer drug IMGN289. IMGN289 is a so-called antibody-drug conjugate (ADC). ADCs combine antibodies (immune system proteins designed to bind to specific targets) with chemotherapy drugs to help steer the chemotherapy agents specifically towards tumors and spare healthy tissues. IMGN289 consists of an antibody that binds to EGFR, a protein expressed in many lung cancer tumors, connected to a cell-killing agent called DM1. The trial will study patients with non-small cell lung cancer (NSCLC) and other cancers that express high levels of EGFR. After determining the highest IMGN289 dose that can safely be administered to patients, the study will evaluate the effectiveness of the drug in different patient subgroups.