“A study by the Columbia University Nova York, in collaboration with the Catalan Institute of Oncology , Belvitge Biomedical Research Institute (ICO-IDIBELL) has identified two new genes that lead to more aggressive forms of prostate cancer. The work done by Alvaro Aytes under the direction of Cory Abate-Shen, director of the Herbert Irving Comprehensive Cancer Center of the Columbia University, has been published in the latest issue of Cancer Cell.”
Editor’s note: More and more, oncologists are using tumor genetics to better understand and treat cancer. Learn more here.
Xu N, Jia D ... Ge D, Bai C, PLoS One, Mar 25, 2013
In this study, we assessed the expression levels of FoxM1 using IHC staining in a cohort of 175 Chinese NSCLC patients and for first time demonstrated that elevated expression of FoxM1 was correlated with several clinicopathological factors and predicted an unfavorable prognosis in NSCLC patients, including SCC and AC. Moreover, we found that the deregulation of FoxM1 expression was significantly associated with higher metastatic abilities through inducing EMT.