Data Emerge on New Immunotherapeutic Targets for Melanoma

Excerpt:

“Several trials either have been completed or are underway to evaluate new immunotherapeutic targets for patients with melanoma, according to a presenter at HemOnc Today New York.

” ‘When we think about where we’re going with immune therapy, it’s important to realize where we are and where have we been,’ Michael A. Postow, MD, assistant attending physician on the melanoma-sarcoma service at Memorial Sloan Kettering Cancer Center, said during his presentation. ‘What are the targets we have been using, and how do we modify what we know and explore totally new territory to try to improve outcomes?’ ”

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Salvage Immunotherapy Viable for Non-Small Cell Lung Cancer

Excerpt:

“Immunotherapy remains a viable option for pretreated patients with non-small cell lung cancer, but the data are rapidly evolving, according to a presenter at HemOnc Today New York.

” ‘We have come a long way with the development of checkpoint inhibitors, and we have to remember that they became famous and exerted their effect in the chemotherapy-refractory setting first,’ Benjamin Levy, MD, assistant professor of oncology at Johns Hopkins University and clinical director of Sidney Kimmel Cancer Center at Sibley Memorial Hospital in Washington, said during his presentation.”

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Interest Builds in Targeting MET Mutations in Non-Small Cell Lung Cancer

Excerpt:

“Although checkpoint blockade immunotherapies have advanced rapidly in the treatment paradigm for patients with non–small cell lung cancer (NSCLC), interest in developing targeted therapies for this malignancy has remained high. Building on the success of molecularly targeted drugs aimed at relatively small subsets of patients, researchers are increasingly aiming at the MET oncogene.

“During the past several years, interest in MET activity has grown as investigators have considered it both as a biomarker and target for treatment, particularly since the focus on MET exon 14 skipping mutations has led to the development of several second-generation MET inhibitors, according to Balazs Halmos, MD, MS.”

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Ramalingam Highlights Immunotherapy Advances in NSCLC

Excerpt:

“Recently reported updates from the KEYNOTE-189 and IMpower150 trials demonstrated the powerful impact of adding immunotherapy to treatment regimens for patients with non–small cell lung cancer (NSCLC).

“In the phase III KEYNOTE-189 study, the combination of pembrolizumab (Keytruda) with chemotherapy in the frontline setting improved survival in patients with nonsquamous NSCLC. In this trial, which is the confirmatory trial for the FDA approval of pembrolizumab plus carboplatin/pemetrexed, patients received frontline pembrolizumab or placebo combined with pemetrexed and either cisplatin or carboplatin. The study met the primary endpoints of improved overall survival (OS) and progression-free survival (PFS), though full data have yet to be presented.”

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ctDNA Can Flag Pseudoprogression in Melanoma Treated With Immunotherapy

Excerpt:

“Circulating tumor DNA (ctDNA) can help differentiate what is known as pseudoprogression from true progression of disease in patients with melanoma who are treated with programmed death 1 (PD-1) inhibitors, according to a new study. It also showed that ctDNA could be used as a powerful biomarker to predict long-term outcomes.

” ‘Pseudoprogression, a response that occurs after the initial development of new lesions or an increase in the size of target lesions, occurs in up to 10% of patients treated with PD-1 antibodies,’ wrote study authors led by Jenny H. Lee, MBBS, of Macquarie University in Sydney, Australia. ‘Confirmation of pseudoprogression requires subsequent imaging, imposing an ongoing challenge.’ ”

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Frontline Nivolumab/Ipilimumab Improves PFS in High TMB NSCLC

Excerpt:

“The combination of nivolumab (Opdivo) and ipilimumab (Yervoy) improved progression-free survival (PFS) compared with chemotherapy in treatment-naïve patients with high tumor mutation burden (TMB) non–small cell lung cancer (NSCLC).

“Bristol-Myers Squibb (BMS), the manufacturer of both immunotherapies, announced the preliminary findings from part 1a of the phase III CheckMate-227 trial in a press release. The company did not report any further data.”

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Some Melanoma Respond to Immunotherapy Beyond Progression

Excerpt:

“Some patients with unresectable or metastatic melanoma who receive immunotherapy and continue therapy after progression have decreased tumor burden, and survival is improved when the therapy is continued as well, according to a new pooled analysis.

“Since the approval of immune therapies for melanoma, concerns have been raised regarding the adequacy of standard RECIST criteria to identify responses and progression. ‘Patients who receive immunotherapy might develop an atypical response pattern, wherein they initially meet conventional response criteria for progressive disease but later have decreases in tumor burden,’ wrote study authors led by Julia A. Beaver, MD, of the US Food and Drug Administration in Silver Spring, Maryland.”

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Metastatic Melanoma Patients May Benefit From Beta Blockers

Excerpt:

“Beta blockers appear to affect immune cells and improve immune function, and now investigators are reporting that beta blockers may play an important role in boosting immunotherapy in patients with metastatic melanoma. Researchers at Penn State University conducted a retrospective study and found that melanoma patients who received immunotherapy while taking a pan beta blocker lived longer than patients who received immunotherapy alone.”

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Proscavax Reduces Prostate Cancer Disease Progression

Excerpt:

“Phase 1a study results showed ProscaVax increased PSA doubling time and increased immunity to PSA, according to a manufacturer-issued press release.

“ProscaVax (OncBioMune Pharmaceuticals) is a novel immunotherapeutic cancer vaccine consisting of a combination of PSA and interleukin-2 and granulocyte-macrophage colony stimulating factor.”

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