ADT Linked to Acute Kidney Injury Risk in Nonmetastatic Prostate Cancer

“Androgen deprivation therapy (ADT) was significantly associated with an increased risk for acute kidney injury among men with nonmetastatic prostate cancer, according to study results. ‘Although ADT has been shown to have beneficial effects on prostate cancer progression, serious adverse events can occur during treatment,’ Francesco Lapi, PharmD, PhD, of the Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, and colleagues wrote. ‘By lowering testosterone to castration levels, ADT may antagonize the vasodilating effects of testosterone on renal vessels while also creating an estrogen deficiency, which can negatively affect renal tubular function. Thus, it is possible that through these mechanisms, the use of ADT may increase the risk of acute kidney injury.’ “

Hormone Use in Prostate Cancer May Harm Kidneys

“Men with nonmetastatic prostate cancer had a significantly increased risk of acute kidney injury when treated with androgen deprivation therapy (ADT), data from a retrospective analysis showed. Current use of any form of ADT more than doubled the odds of acute kidney injury as compared with men not receiving ADT, according to Samy Suissa, PhD, of Jewish General Hospital in Montreal, and co-authors. The strongest effect on kidney injury came from combined treatment with gonadotropin-releasing hormone (GnRH) agonists and antiandrogens, followed by estrogen, other combination therapies, and GnRH monotherapy. Bilateral orchiectomy and monotherapy with an antiandrogen did not significantly affect the risk of acute kidney injury, they reported online in JAMA.”