“The PREVAIL trial showed that enzalutamide (Xtandi) improved overall survival and progression-free survival vs placebo in asymptomatic/minimally symptomatic chemotherapy-naive patients with metastatic castration-resistant prostate cancer. In analyses reported in The Lancet Oncology, Loriot et al found that enzalutamide treatment was associated with improved patient-reported outcomes and an increased time to first skeletal-related event in the trial.
“In the double-blind trial, patients were randomly assigned to receive enzalutamide 160 mg/d (n = 872) or placebo (n = 845). Health-related quality of life was assessed at baseline and during treatment using the Functional Assessment of Cancer Therapy-Prostate (FACT-P) and EuroQol-5 dimension (EQ-5D) questionnaires. Pain status was assessed at screening, baseline, week 13, and week 25 with the Brief Pain Inventory Short Form (BPI-SF).
“Significant between-treatment differences in change from baseline to week 61 for enzalutamide vs placebo were observed for most FACT-P endpoints and the EQ-5D visual analog scale. Median time to deterioration in FACT-P total score was 11.3 months vs 5.6 months (hazard ratio [HR] = 0.62, P < .0001). Clinically meaningful improvements were observed for the FACT-P total score in 40% vs 23%, for the EQ-5D utility index in 28% vs 16%, and for the EQ-5D visual analog scale in 27% vs 18% (P < .0001 for all comparisons)…
“The investigators concluded: ‘In addition to improving overall survival relative to placebo, enzalutamide significantly improves patient-related outcomes and delays occurrence of first skeletal-related event in chemotherapy-naive men with metastatic castration-resistant prostate cancer.’ ”