DCIS Survival Benefit from Surgery Varies by Nuclear Grade

“Surgical management of ductal carcinoma in situ improved survival outcomes compared with non-operative management among patients with high-grade disease but not among those with low-grade disease, according to results of a SEER analysis presented at the ASCO Annual Meeting.

“Although the current standard of care for ductal carcinoma in situ (DCIS) includes lumpectomy or mastectomy, surgical benefit was never fully established in this setting, according to study background.

“ ‘Our objective was to investigate whether there is a survival benefit offered by surgical treatment in patients with DCIS based on nuclear grade,’ Yasuaki Sagara, MD, a research fellow in surgery in the department of surgery at Brigham and Women’s Hospital in Boston, said during his presentation.

“Sagara and colleagues identified 57,222 eligible cases of DCIS that occurred between 1998 and 2011 using data from the SEER database.”