Trial of New Lung Cancer Drug OGX-427 Now Enrolling Participants

The Spruce trial, a phase II clinical trial examining the effectiveness of the cancer drug OGX-427 in non-small cell lung cancer (NSCLC), is now open for enrollment. The trial will study patients with previously untreated, advanced non-squamous NSCLC. They will receive the chemotherapy agents carboplatin (Paraplatin) and pemetrexed (Alimta) in combination with either OGX-427 or a placebo. The sponsors also plan to add the Cedar trial, which will investigate the use of OGX-427 in squamous cell NSCLC. OGX-427 inhibits Hsp27, a protein that is highly expressed in many tumor cells. The drug may be especially promising for patients without mutations that make them eligible for currently available targeted therapies.


Two Upcoming Clinical Trials to Investigate New Lung Cancer Drug OGX-427

OncoGenex Pharmaceuticals plans to launch two phase II clinical trials of its new cancer drug, OGX-427, in lung cancer patients. The Cedar trial will be conducted by the UK National Cancer Research Network and the UK Experimental Cancer Medicine Network at cancer centers throughout the UK. It will examine the effectiveness of OGX-427 in combination with chemotherapy in previously untreated patients with advanced squamous cell carcinoma (SCC) of the lung, a type of non-small cell lung cancer (NSCLC). The Spruce trial will be performed in the U.S. in collaboration with the Sarah Cannon Research Institute and will enroll patients with advanced non-squamous NSCLC. OGX-427 inhibits Hsp27, a protein that is overexpressed in many cancer cells.


New Clinical Trial of Drug OGX-427 Aims to Help Patients Ineligible for Targeted Therapies

OncoGenex Pharmaceuticals announced that it will begin the Spruce clinical trial, a phase II study investigating the use of their cancer drug OGX-427 in non-small cell lung cancer (NSCLC). Patients with advanced non-squamous NSCLC will receive first-line treatment with chemotherapy using carboplatin (Paraplatin) and pemetrexed (Alimta), either with or without the addition of OGX-427. OGX-427 inhibits a protein called Hsp27, which is elevated in many cancers. The study investigators suggest that OGX-427 may be especially helpful for patients whose cancers lack certain mutations that would make them eligible for currently available targeted therapies.


Hsp27 regulates epithelial mesenchymal transition, metastasis and circulating tumor cells in prostate cancer

We observed a correlation between Hsp27 and Twist in PCa patients, with Hsp27 and Twist expression each elevated in high grade PCa tumors. Hsp27 inhibition by OGX-427, an antisense therapy currently in Phase II trials, reduced tumor metastasis in a murine model of PCa. More importantly, OGX-427 treatment decreased the number of circulating tumor cells in patients with metastatic castration-resistant PCa in a Phase I clinical trial. Overall, this study defines Hsp27 as a critical regulator of IL-6 dependent and independent EMT, validating this chaperone as a therapeutic target to treat metastatic PCa.”