Low-Fat Fish Oil Diet May Alter Prostate Tumor Biology

“Men with early stage prostate cancer who ate a low-fat diet supplemented with fish oil had lower amounts of proinflammation molecules in their blood and lower prostate tumor cell proliferation compared with men who ate a high-fat Western diet. Men on the low-fat fish oil diet had lower serum levels of omega-6 fatty acids and high levels of serum omega-3 fatty acids compared with the prostate cancer patients who consumed a Western diet. The experimental group also had lower levels of the proinflammatory eicosanoid 15(S)-hydroxyeicosatetraenoic acid, or 15(S)-HETE, which has been previously shown to be associated with cancer. The decline in mean 15(S)-HETE was 7.2% in the low-fat diet group compared with 24.7% in the high-fat diet group (P = .02). The men in the low-fat diet group also had a lower cell cycle progression score, a marker for the aggressiveness of a cancer.”