Work stress very unlikely to cause cancer new study shows

Work-related stress is not linked to the development of colorectal, lung, breast or prostate cancers, a new study suggests. Around 90% of cancers are linked to environmental exposures and whilst some exposures are well recognised (such as UV radiation and tobacco smoke), others are not (psychological factors such as stress).

Comparative Effectiveness of Alternative PSA–Based Prostate Cancer Screening Suggests Varying PSA Screening for Older Men May Be Beneficial

Compared with standard screening, PSA screening strategies that use higher thresholds for biopsy referral for older men and that screen men with low PSA levels less frequently can reduce harms while preserving lives.

Receptor tyrosine kinase Axl is essential regulator of prostate cancer proliferation and could be new therapeutic target

Axl is consistently overexpressed in prostate cancer cell lines and human prostate tumors. Blocking Axl gene expression strongly inhibits proliferation, migration, invasion and tumor growth researchers find. Results may have implications for new treatment development

PCF, Sanofi initiate text message support program for men on chemotherapy

The Prostate Cancer Foundation (PCF) and Sanofi have initiated a new, one-way, text message-based support program called Prost8Care for men with advance prostate cancer to reinforce healthcare guidances on treatment, side effects, and diet.

Team of scientists evaluate different ways to help make PSA screening decision

How PSA screening informtion is presented effects a man’s decision to be screened for prostate cancer. The researchers described PSA screening decision options as 4 key attributes: effect on prostate cancer mortality, risk of biopsy, risk of being diagnosed with prostate cancer and risk of becoming impotent or incontinent as a result of treatment and presented the information in 3 formats.

Exercise Linked With Reduced Prostate Cancer Risk In Caucasians But Not African Americans

A new study suggests that exercise may reduce Caucasian men’s risk of developing prostate cancer. And among Caucasian men who do have prostate cancer, exercise may reduce their risk of having more serious forms of the disease. The benefits do not seem to apply to African- American men according to this study published in CANCER.

Researchers Identify Genetic Root to Early-Onset Prostate Cancer Using Integrative Genomic Analyses

Researchers compared the genomic alterations of early onset prostate cancer which makes up about 2% of prostate cancers with that of “classical” (elderly-onset) prostate cancer to find age-related differences including abundance of androgen-regulated ETS gene fusions amongst other differences. The findings could help in the development of new diagnostic, prognostic, therapeutic, and prevention strategies for the disease.

Phase III Clinical Trial of Oral Toremifene for prostate cancer prevention among men with isolated high-grade intraepithelial neoplasia

Toremifene 20 mg did not lower the prostate cancer detection rate in the phase III study, but men with isolated high-grade prostatic intraepithelial neoplasia (PIN) do have a high likelihood of eventual PCa diagnosis. The authors recommend that these men be included in chemoprevention trials and are monitored by periodic prostate biopsy.

Expert Clinical Opinion on prostatic intraepithelial neoplasia (PIN)

Post two large-scale PIN-to-cancer chemoprevention trials, the authors discourage aggressive rebiopsy of patient with PIN unless a risk assessment tool suggests a high likelihood of a high-grade tumor that was missed on biopsy.