“A new study has found that children whose parents are melanoma survivors are not receiving the best possible protection from the sun and ultraviolet radiation.
“This lack of protection can lead to sunburn, increasing the risk of melanoma for the children, who already face a substantially higher risk of developing the skin cancer due to their family history.
“Melanoma is the most serious form of skin cancer as well as one of the most common. In the US, in 2014, it was estimated that 76,100 new melanomas would be diagnosed with around 9,710 people dying from the disease. According to the American Cancer Society, melanoma rates have been rising for the past 30 years.
“The authors of the study, published in Cancer Epidemiology, Biomarkers & Prevention, state that childhood is estimated to be one of the most critical exposure periods for conferring risk.”
Hodi FS, Corless CL, Giobbie-Hurder A, Fletcher JA, et al. J Clin Oncol. Jun 17, 2013.
“Amplifications and mutations in the KIT proto-oncogene in subsets of melanomas provide therapeutic opportunities…We conducted a multicenter phase II trial of imatinib in metastatic mucosal, acral, or chronically sun-damaged (CSD) melanoma with KIT amplifications and/or mutations…Melanomas that arise on mucosal, acral, or CSD skin should be assessed for KIT mutations. Imatinib can be effective when tumors harbor KIT mutations, but not if KIT is amplified only. NRAS mutations and KIT copy number gain may be mechanisms of therapeutic resistance to imatinib.“