VeriStrat Status Predicts Responsiveness to Tarceva Treatment in Elderly Lung Cancer Patients

VeriStrat® is a blood test for advanced non-small cell lung cancer (NSCLC) patients intended to determine whether the patients would benefit from erlotinib (Tarceva) treatment. A retrospective analysis of blood samples from elderly patients (age 70+ yr) with advanced NSCLC who had been treated with either Tarceva, gemcitabine (Gemzar), or both found that patients with a “good” VeriStrat result had better outcomes than those with a “poor” result when given Tarceva either alone or in combination with Gemzar, while the benefits of Gemzar alone were unaffected by VeriStrat status. The study authors conclude that elderly patients with poor VeriStrat results should be treated with Gemzar, while first-line Tarceva treatment may be appropriate for patients with good Veristrat results.

TKIs Are Effective First-Line Treatment in EGFR-Mutant Advanced NSCLC

Four phase III studies compared the tyrosine kinase inhibitors (TKIs) erlotinib (Tarceva) or gefitinib (Iressa) to standard chemotherapy as first-line treatment for EGFR-mutant advanced non-small cell lung cancer (NSCLC). TKI treatment increased progression-free survival (ie, the length of time without the cancer worsening), but did not improve overall survival compared to chemotherapy. In one study, TKI-treated patients maintained a higher quality of life for longer than chemotherapy-treated patients. The findings suggest that TKI treatment should become the standard first-line treatment in advanced NSCLC with mutations in the EGFR gene.

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