The Challenge
After two unsuccessful lines of chemotherapy, Ramona faced rapidly progressing disease and few remaining treatment options.
Our Impact
Cancer Commons recommended comprehensive mutational analysis, which revealed a rare gene alteration. Only a single case report existed in the literature describing response to immune checkpoint drugs in patients with this alteration—but it offered a potential path forward.
The Outcome
The patient enrolled in a clinical trial with an immune checkpoint inhibitor and experienced a remarkable response, with disease control lasting more than three years.
