Patient Story

Avoiding Costly Mismatches: Susan's Precision Treatment Story

Susan's oncologist at a leading academic center was about to prescribe Rybrevant based on her biomarker reports. Cancer Commons identified a critical distinction—her tumor had ERBB2 alterations, not EGFR mutations that Rybrevant targets. We clarified that Enhertu was the evidence-supported therapy for her biomarker profile.

The Challenge

Susan's oncologist at a leading academic center was about to prescribe Rybrevant based on her biomarker reports.

Our Impact

Cancer Commons identified a critical distinction—her tumor had ERBB2 alterations, not EGFR mutations that Rybrevant targets. We clarified that Enhertu was the evidence-supported therapy for her biomarker profile.

The Outcome

Near-complete resolution of liver and bone metastases within weeks. She avoided wasting time on an ineffective therapy that, at the time, would have cost thousands of dollars per month.

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Cancer Commons is a non-profit network of patients, scientists, and physicians united by a shared goal—to optimize each patient’s outcome and maximize collective learning to benefit the next patient.